Aryl Hydrocarbon Hydroxylases
Synonyms
Hydroxylases, Aryl Hydrocarbon
Microsomal Monooxygenases
Monooxygenases, Microsomal
Monooxygenases, Xenobiotic
Xenobiotic Monooxygenases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.