beta-N-Acetylhexosaminidases
Synonyms
N Acetyl beta D hexosaminidase
N-Acetyl-beta-D-hexosaminidase
beta Hexosaminidase
beta N Acetyl D hexosaminidase
beta N Acetyl hexosaminidase
beta N Acetylhexosaminidase
beta N Acetylhexosaminidases
beta-Hexosaminidase
beta-N-Acetyl-D-hexosaminidase
beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
beta-N-Acetyl-hexosaminidase
beta-N-Acetylhexosaminidase
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.