Buthionine Sulfoximine
Synonyms
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Sulfoximine, Buthionine
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)