Cytochrome-B(5) Reductase
Synonyms
B5 Reductase, NADH-Cytochrome
Methemoglobin Reductase
Methemoglobin Reductase, NADH
NADH Cytochrome B5 Reductase
NADH Ferrihemoglobin Reductase
NADH Methemoglobin Reductase
NADH-Cytochrome B5 Reductase
NADH-Ferrihemoglobin Reductase
Reductase, Methemoglobin
Reductase, NADH Methemoglobin
Reductase, NADH-Ferrihemoglobin
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.