Dapsone

Synonyms

4,4' Diaminophenyl Sulfone

4,4'-Diaminophenyl Sulfone

Avlosulfone

DADPS

Dapsoderm-X

Dapson-Fatol

Diaminodiphenylsulfone

Diaphenylsulfone

Disulone

Sulfona

Sulfone, 4,4'-Diaminophenyl

Sulfonyldianiline

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)