DNA-(Apurinic or Apyrimidinic Site) Lyase

Synonyms

AP Endonuclease

AP Lyase

Apurine Apyrimidine Endonuclease

Apurine-Apyrimidine Endonuclease

Apurinic DNA Endonuclease

Apurinic Endonuclease

DNA Endonuclease, Apurinic

DNA Lyase (Apurinic or Apyrimidinic)

Endodeoxyribonuclease (Apurinic or Apyrimidinic)

Endonuclease, AP

Endonuclease, Apurine-Apyrimidine

Endonuclease, Apurinic

Endonuclease, Apurinic DNA

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.