Donohue Syndrome
Synonyms
Leprechaunism
Leprechaunisms
Mendenhall Syndrome
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Rabson Mendenhall Syndrome
Rabson-Mendenhall Syndrome
Syndrome, Donohue
Syndrome, Mendenhall
Syndrome, Rabson-Mendenhall
Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.