Glioblastoma
Synonyms
Astrocytoma, Grade IV
Astrocytomas, Grade IV
Giant Cell Glioblastoma
Giant Cell Glioblastomas
Glioblastoma Multiforme
Glioblastoma, Giant Cell
Glioblastomas
Glioblastomas, Giant Cell
Grade IV Astrocytoma
Grade IV Astrocytomas
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.