Glutamate Decarboxylase
Synonyms
Acid Decarboxylase, Glutamic
Carboxy-Lyase, Glutamate
Decarboxylase, Glutamate
Decarboxylase, Glutamic Acid
Glutamate Carboxy Lyase
Glutamate Carboxy-Lyase
Glutamic Acid Decarboxylase
L-Glutamate-1-carboxy-lyase
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.