Hypoxanthine Phosphoribosyltransferase
Synonyms
Guanine Phosphoribosyltransferase
HGPRT
HPRT
HPRTase
Hypoxanthine Guanine Phosphoribosyltransferase
Hypoxanthine-Guanine Phosphoribosyltransferase
IMP Pyrophosphorylase
IMP:pyrophosphate phospho-D-ribosyltransferase
Phosphoribosyltransferase, Guanine
Phosphoribosyltransferase, Hypoxanthine
Phosphoribosyltransferase, Hypoxanthine-Guanine
Pyrophosphorylase, IMP
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
See Also