Lovastatin

Synonyms

1 alpha-Isomer Lovastatin

6 Methylcompactin

6-Methylcompactin

Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-

Lovastatin, (1 alpha(S*))-Isomer

Lovastatin, 1 alpha Isomer

Lovastatin, 1 alpha-Isomer

MK 803

MK-803

MK803

Mevacor

Mevinolin

Monacolin K

alpha-Isomer Lovastatin, 1

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.