Maturation-Promoting Factor
Synonyms
Histone H1 Kinase, Growth Associated
Histone H1 Kinase, Growth-Associated
Histone H1 Kinase, M Phase Specific
Histone H1 Kinase, M-Phase-Specific
M Phase Promoting Factor
M Phase-Promoting Factor
Maturation Promoting Factor
Mitosis Promoting Factor
Mitosis-Promoting Factor
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
See Also