Metabolic Detoxication, Phase I
Synonyms
Detoxication, Oxidative Metabolic
Detoxications, Oxidative Metabolic
Detoxification, Phase I
Detoxifications, Phase I
Metabolic Detoxication, Oxidative
Metabolic Detoxications, Oxidative
Metabolic Detoxification, Phase I
Oxidative Metabolic Detoxication
Oxidative Metabolic Detoxications
Phase I Detoxification
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
See Also