Miller Fisher Syndrome

Synonyms

Fisher Syndrome

Guillain Barre Syndrome, Miller Fisher Variant

Guillain-Barre Syndrome, Miller Fisher Variant

Miller Fisher Variant of Guillain Barre Syndrome

Miller-Fisher Syndrome

Ophthalmoplegia, Ataxia and Areflexia Syndrome

Syndrome, Fisher

Syndrome, Miller Fisher

Syndrome, Miller-Fisher

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)