Myelinolysis, Central Pontine
Synonyms
Central Pontine Myelinoclasis
Central Pontine Myelinolysis
Extrapontine Myelinoclases
Extrapontine Myelinoclasis
Extrapontine Myelinolyses
Extrapontine Myelinolysis
Myelinoclases, Extrapontine
Myelinoclasis, Central Pontine
Myelinoclasis, Extrapontine
Myelinolyses, Extrapontine
Myelinolysis, Extrapontine
Pontine Myelinolysis, Central
A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)