Ophthalmoplegia, Chronic Progressive External
Synonyms
CPEO
Chronic Progressive External Ophthalmoplegia
Disease, Graefe
Dystrophy, Ocular Muscular
External Ophthalmoplegia, Progressive
Graefe Disease
Graefe's Disease
Mitochondrial Ocular Myopathy
Muscular Dystrophies, Ocular
Muscular Dystrophy, Ocular
Myopathy, Mitochondrial Ocular
Ocular Muscular Dystrophies
Ocular Muscular Dystrophy
Ocular Myopathy of Von Graefe Fuchs
Ocular Myopathy of Von Graefe-Fuchs
Ocular Myopathy, Mitochondrial
Ophthalmoplegia, Progressive External
Progressive External Ophthalmoplegia
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)