P-Glycoprotein
Synonyms
ABCB1 Protein
ATP-Binding Cassette, Sub-Family B, Member 1
Antigen, CD243
CD243 Antigen
MDR1 Protein
Multidrug Resistance Protein 1
P Glycoprotein
PGY 1 Protein
PGY-1 Protein
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
See Also