Polymorphism, Single-Stranded Conformational

Synonyms

Conformational Polymorphism, Single-Stranded

Conformational Polymorphisms, Single-Stranded

Polymorphism, Single Stranded Conformational

Polymorphisms, Single-Stranded Conformational

SSCP

Single Stranded Conformational Polymorphism

Single-Stranded Conformational Polymorphism

Single-Stranded Conformational Polymorphisms

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.