Protein Tyrosine Phosphatase, Non-Receptor Type 22

Synonyms

Lymphoid Phosphatase

Lyp1 PTPase

Lyp2 PTPase

PTPN 22 Protein

PTPN-22 Protein

PTPase Lyp

PTPase, Lyp1

PTPase, Lyp2

Protein Tyrosine Phosphatase Lyp

Protein Tyrosine Phosphatase, Non Receptor Type 22

Protein-Tyrosine Phosphatase Lyp

Tyrosine Protein Phosphatase, Non Receptor Type 22

Tyrosine Protein Phosphatase, Non-Receptor Type 22

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.