PTEN Phosphohydrolase
Synonyms
MMAC1 Protein
Mutated In Multiple Advanced Cancers 1 Protein
PTEN Phosphatase
PTEN Protein
PTEN Protein Phosphatase
Phosphatase and Tensin Homologue on Chromosome Ten Protein
Phosphatase, PTEN
Phosphatase, PTEN Protein
Phosphohydrolase, PTEN
Protein Phosphatase, PTEN
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.