Steroid 12-alpha-Hydroxylase
Synonyms
12 alpha Hydroxylase
12 alpha-Hydroxylase, Sterol
12-alpha-Hydroxylase
12alpha Hydroxylase
12alpha-Hydroxylase
CYP8B1
Cytochrome P450 8B1
Cytochrome P450 CYP8B1
Steroid 12 Hydroxylase
Steroid 12 Monooxygenase
Steroid 12 alpha Hydroxylase
Steroid 12-Hydroxylase
Steroid 12-Monooxygenase
Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Steroid-12-Hydroxylase
Steroid-12-Monooxygenase
Sterol 12 alpha Hydroxylase
Sterol 12 alpha-Hydroxylase
Sterol 12-alpha-Hydroxylase
alpha-Hydroxylase, Sterol 12
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.