T-Lymphocytes, Cytotoxic

Synonyms

Cell Mediated Lympholytic Cells

Cell, Cell-Mediated Lympholytic

Cell, TC1

Cell, TC2

Cell-Mediated Lympholytic Cell

Cell-Mediated Lympholytic Cells

Cells, Cell-Mediated Lympholytic

Cells, TC1

Cells, TC2

Cytotoxic T Lymphocytes

Cytotoxic T-Lymphocyte

Cytotoxic T-Lymphocytes

Lympholytic Cell, Cell-Mediated

Lympholytic Cells, Cell-Mediated

T Lymphocytes, Cytotoxic

T-Lymphocyte, Cytotoxic

TC1 Cell

TC1 Cells

TC2 Cell

TC2 Cells

Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.