5-Aminolevulinate Synthetase

Synonyms

5 Aminolevulinate Synthase

5 Aminolevulinate Synthetase

5-Aminolevulinate Synthase

Acid Synthetase, Aminolevulinic

Acid Synthetase, delta-Aminolevulinic

Aminolevulinic Acid Synthetase

Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)

Synthase, 5-Aminolevulinate

Synthase, delta-Aminolevulinate

Synthetase, 5-Aminolevulinate

Synthetase, Aminolevulinic Acid

Synthetase, delta-Aminolevulinic Acid

delta Aminolevulinate Synthase

delta Aminolevulinic Acid Synthetase

delta-Aminolevulinate Synthase

delta-Aminolevulinic Acid Synthetase

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.