AC133 Antigen
Synonyms
AC133 1 Antigen
AC133 2 Antigen
AC133-1 Antigen
AC133-2 Antigen
AC141 Antigen
Antigen, AC133
Antigen, AC133-1
Antigen, AC133-2
Antigen, AC141
Antigen, CD133
CD133 Antigen
Fudenine
PROML1
PROML1, Prominin-Like
Prominin
Prominin 1
Prominin Like PROML1
Prominin-1
Prominin-Like PROML1
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
See Also