ADAM17 Protein
Synonyms
ADAM 17 Protein
ADAM-17
ADAM-17 Protein
Antigen, CD156b
CD156b Antigen
Convertase, TNF-alpha
Disintegrin and Metalloproteinase Domain Containing Protein 17
Disintegrin and Metalloproteinase Domain-Containing Protein 17
TACA (Enzyme)
TACE (Enzyme)
TNF alpha Convertase
TNF alpha Converting Enzyme
TNF-alpha Convertase
TNF-alpha Converting Enzyme
Tumor Necrosis Factor Alpha Convertase
Tumor Necrosis Factor alpha Converting Enzyme
Tumor Necrosis Factor-alpha Convertase
Tumor Necrosis Factor-alpha Converting Enzyme
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.