Adrenoleukodystrophy
Synonyms
ALD (Adrenoleukodystrophy)
Addison Disease and Cerebral Sclerosis
Adrenoleukodystrophy, X-Linked
Adrenomyeloneuropathy
Bronze Schilder Disease
Leukodystrophies, Melanodermic
Leukodystrophy, Melanodermic
Melanodermic Leukodystrophy
Schilder Addison Complex
Schilder-Addison Complex
Siemerling Creutzfeldt Disease
Siemerling-Creutzfeldt Disease
X ALD
X ALD (X Linked Adrenoleukodystrophy)
X Linked Adrenoleukodystrophy
X-ALD
X-ALD (X-Linked Adrenoleukodystrophy)
X-Linked Adrenoleukodystrophy
An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).