Angiotensinogen
Synonyms
Angiotensinogen (protein renin substrate)
Hypertensinogen
Proangiotensin
Renin Substrate
Renin Substrate Tetradecapeptide
Renin-Substrate
Serpin A8
Tetradecapeptide, Renin Substrate
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.