Antigenic Variation

Synonyms

Antigen Switching

Antigen Variation

Antigenic Diversity

Antigenic Switching

Antigenic Variability

Diversity, Antigenic

Switching, Antigen

Switching, Antigenic

Variability, Antigenic

Variation, Antigen

Variation, Antigenic

Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)