BRCA1 Protein
Synonyms
BRCA1 Gene Product
Breast Cancer 1 Gene Product
Breast Cancer 1 Protein
Breast Cancer Type 1 Susceptibility Protein
Ring Finger Protein 53
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)