Cholera Toxin
Synonyms
CT, Cholera Enterotoxin
Cholera Enterotoxin CT
Cholera Exotoxin
Cholera Toxin A Subunit
Cholera Toxin B Subunit
Cholera Toxin Protomer A
Cholera Toxin Protomer B
Choleragen
Choleragenoid
Enterotoxin CT, Cholera
Exotoxin, Cholera
Procholeragenoid
Toxin, Cholera
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.