Cholesterol Side-Chain Cleavage Enzyme
Synonyms
20,22 Desmolase
20,22-Desmolase
CYP 11A1
CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cholesterol Side Chain Cleavage Enzyme
Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Cytochrome P 450 CYP11A1
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
Cytochrome P450 11A1
Cytochrome P450scc
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.