Cisplatin
Synonyms
Biocisplatinum
Diamminodichloride, Platinum
Dichlorodiammineplatinum
NSC-119875
Platidiam
Platino
Platinol
Platinum Diamminodichloride
Platinum, diamminedichloro-, (SP-4-2)-
cis Diamminedichloroplatinum
cis Platinum
cis-Diamminedichloroplatinum
cis-Diamminedichloroplatinum(II)
cis-Dichlorodiammineplatinum(II)
cis-Platinum
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.