Costello Syndrome
Synonyms
FCS Syndrome
FCS Syndromes
Faciocutaneoskeletal Syndrome
Faciocutaneoskeletal Syndromes
Syndrome, Costello
Syndrome, FCS
Syndrome, Faciocutaneoskeletal
Syndromes, FCS
Syndromes, Faciocutaneoskeletal
Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).