Dactinomycin

Synonyms

Ac-De

Actinomycin

Actinomycin D

Cosmegen

Cosmegen Lyovac

Lemery Brand of Dactinomycin

Lyovac, Cosmegen

Lyovac-Cosmegen

MSD Brand of Dactinomycin

Meractinomycin

Merck Brand of Dactinomycin

Merck Frosst Brand of Dactinomycin

Merck Sharp & Dohme Brand of Dactinomycin

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)