Fibroblast Growth Factor 2
Synonyms
Basic Fibroblast Growth Factor
Cartilage Derived Growth Factor
Cartilage-Derived Growth Factor
Class II Heparin-Binding Growth Factor
FGF 2
FGF-2
FGF2
Fibroblast Growth Factor, Basic
Fibroblast Growth Factor-2
HBGF-2
Heparin-Binding Growth Factor Class II
Prostate Epithelial Cell Growth Factor
Prostatropin
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).