Flap Endonucleases

Synonyms

Endonuclease-1, Flap

Endonucleases, Flap

FEN-1

Fen1 Protein

Flap Endonuclease 1

Flap Endonuclease-1

Nuclease, RTH-1

RAD2 Homolog 1 Nuclease

RAD2 Homolog-1 Nuclease

RTH 1 Nuclease

RTH-1 Nuclease

Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.