Focal Adhesion Kinase 1
Synonyms
Endogenous Substrate pp120
Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
Protein Tyrosine Kinase 2
p125FAK Protein
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.