Formate-Tetrahydrofolate Ligase
Synonyms
Formate Tetrahydrofolate Ligase
Formate:tetrahydrofolate ligase (ADP-forming)
Formylase, Tetrahydrofolate
Formyltetrahydrofolate Synthetase
Ligase, Formate-Tetrahydrofolate
Synthetase, Formyltetrahydrofolate
Tetrahydrofolate Formylase
A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.