Methylenetetrahydrofolate Dehydrogenase (NADP)
Synonyms
5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
Dehydrogenase, Methylenetetrahydrofolate
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.