GTP Cyclohydrolase

Synonyms

7,8 Dihydroneopterintriphosphate Synthetase

7,8-Dihydroneopterintriphosphate Synthetase

8-Formylhydrolase, GTP

Cyclohydrolase I, GTP

Cyclohydrolase II, GTP

Cyclohydrolase, GTP

Dihydrolase, GTP

GTP 7,8-8,9-dihydrolase

GTP 8 Formylhydrolase

GTP 8-Formylhydrolase

GTP Cyclohydrolase I

GTP Cyclohydrolase II

GTP Dihydrolase

GTP Ring Opening Enzyme

GTP Ring-Opening Enzyme

Ring-Opening Enzyme, GTP

Synthetase, 7,8-Dihydroneopterintriphosphate

(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).