Helix-Turn-Helix Motifs
Synonyms
HTH Motif
HTH Motifs
Helix Turn Helix Motifs
Helix-Turn-Helix Motif
Motif, HTH
Motif, Helix-Turn-Helix
Motifs, HTH
Motifs, Helix Turn Helix
Motifs, Helix-Turn-Helix
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)