Hemoglobinuria, Paroxysmal
Synonyms
Cold Paroxysmal Hemoglobinuria
Hemoglobinuria, Cold Paroxysmal
Hemoglobinuria, Nocturnal Paroxysmal
Hemoglobinuria, Paroxysmal Cold
Hemoglobinuria, Paroxysmal Nocturnal
Marchiafava Micheli Syndrome
Marchiafava-Micheli Syndrome
Nocturnal Paroxysmal Hemoglobinuria
Paroxysmal Cold Hemoglobinuria
Paroxysmal Hemoglobinuria
Paroxysmal Hemoglobinuria, Cold
Paroxysmal Hemoglobinuria, Nocturnal
Paroxysmal Nocturnal Hemoglobinuria
Syndrome, Marchiafava-Micheli
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.