Histocompatibility Antigens Class I
Synonyms
Antigens, Class I
Class I Antigens
Class I Histocompatibility Antigens
Class I Human Antigens
Class I Major Histocompatibility Antigens
Human Class I Antigens
I Antigens, Class
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.