Kininogen, High-Molecular-Weight
Synonyms
Fitzgerald Factor
HMWK
High Molecular Weight Kininogen
High Molecular Weight Kininogens
High-Molecular-Weight Kininogen
High-Molecular-Weight Kininogens
Kininogen, High Molecular Weight
Kininogens, High Molecular Weight
Kininogens, High-Molecular-Weight
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)