Mice, Inbred MRL lpr
Synonyms
MRL lpr Mice
MRL lpr Mouse
Mice, MRL lpr
Mouse, Inbred MRL lpr
Mouse, MRL lpr
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.