Neuropilin-1
Synonyms
A5 Antigen
Antigen, A5
NRP1 Protein
Neuropilin 1
Npn 1 Protein
Npn-1 Protein
Receptor, Sema III
Sema III Receptor
Semaphorin III Receptor
A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.