Pick Disease of the Brain
Synonyms
Atrophies, Lobar (Brain)
Atrophy, Lobar (Brain)
Brain Atrophy, Circumscribed Lobar
Circumscribed Lobar Atrophy of the Brain
Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions
Disease, Pick
Disease, Pick's
Lobar Atrophies (Brain)
Lobar Atrophy (Brain)
Lobar Atrophy Of Brain
Lobar Atrophy of the Brain
Pick Disease
Pick Disease Of Brain
Pick's Disease
Picks Disease
Picks Disease of Brain
A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)