Platelet Glycoprotein GPIIb-IIIa Complex
Synonyms
GPIIb IIIa Receptors
GPIIb-IIIa Receptors
Glycoproteins IIb IIIa
Glycoproteins IIb-IIIa
Integrin alpha IIb beta 3
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3
Platelet Glycoprotein GPIIb IIIa Complex
Receptors, GPIIb-IIIa
alphaIIbbeta3, Integrin
beta-3, Integrin alpha-IIb
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
See Also