von Willebrand Factor
Synonyms
Factor VIII Related Antigen
Factor VIII-Related Antigen
Factor VIIIR Ag
Factor VIIIR RCo
Factor VIIIR-Ag
Factor VIIIR-RCo
Plasma Factor VIII Complex
Ristocetin Cofactor
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
See Also