Procollagen-Proline Dioxygenase
Synonyms
4-Hydroxylase, Procollagen Prolyl
Dioxygenase, Procollagen-Proline
Hydroxylase, Protocollagen Prolyl
Procollagen Proline Dioxygenase
Procollagen Prolyl 4 Hydroxylase
Procollagen Prolyl 4-Hydroxylase
Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
Prolyl 4-Hydroxylase, Procollagen
Prolyl Hydroxylase, Protocollagen
Protocollagen Prolyl Hydroxylase
A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
See Also